A Study on the Effects of Surfactant Concentration and Particle Size on Ethylcellulose Microspheres Containing Indinavir Sulphate

Microspheres containing indinavir sulfate were prepared by the emulsion solvent evaporation technique using surfactant sorbitan monooleate 80. The evaluation reports for Fourier-transform infrared spectroscopy and X-ray diffraction taken to see whether altered physicochemical features of produced microspheres. Scanning electron microscopy was used observe surface topography When 80 employed at dissimilar concentrations, microspheres had higher concentrations that resulted in smaller particle size as compared lower microspheres, therefore, faster release rate observed utilizing a concentration entrapped 71 % 96 drug released it up 7 h. revealed decrease crystallinity drug. analysis spherical after dissolution detected porous structure excellent fit kinetics is accomplished with zero-order, Higuchi plot followed first-order, Hixson-Crowell Korsmeyer-Peppas equations. As result, influenced drug-polymer ratio, diffusion mechanism.